Challenges and unseen impacts
People living with hemophilia (PwH) may experience challenges and unseen impacts
![A shield with a plus sign is heavier than a needle on a scale](/dam/jcr:1eb215d3-c3e2-4002-808d-c27e54ec17ac/Scale%201_2x.png)
According to the World Federation of Hemophilia, PwH may be making trade-offs when balancing treatment burden and bleed protection.1
- Bleeding episodes in PwH are accompanied by physical and emotional burdens that can occur before, during, and last beyond the bleeding episode2
Current challenges may include:
![Blue silhouette of humans head and brain in knot](/dam/jcr:e743f8cb-d340-486e-8573-2634bbdd4fea/Emotional_2x%20(1).png)
Emotional2-4
- Emotional burdens*
- Impact on education, recreation, and career
- Social isolation
![Blue silhouette of human with lightning bolts in the elbow, knees, and ankles](/dam/jcr:83a4bba6-7204-462b-9d1a-33292c72c4f6/Physical_2x.png)
Physical
- Different grades of pain1,5
- Concerns about bleed protection6
- Breakthrough bleeds1,5,7
![A blue hospital building with plus sign mapping out destination](/dam/jcr:7534bf52-dabf-4111-a60d-4b7c8c93e316/Logistical%20Icon.png)
Logistical3,8
- Access to treatment centers
- Refrigeration requirements
- Difficulties with scheduling treatment
- Reconstitution requirements
*Emotional burdens include those related to mental health, perception of self, and impact on social life and relationships.2-4
Challenges for PwH with inhibitors
Treatment options are limited for PwH living with inhibitors
For PwH, development of inhibitors represents a significant challenge to treatment, potentially rendering it ineffective and further reducing health-related quality of life compared to people unaffected by inhibitors.9
- The unmet need is greater in PwH with inhibitors, who may require a different treatment10
- People with hemophilia B with inhibitors have been one of the most underserved populations11
PwH may not realize all the ways that hemophilia could be impacting their daily lives.1
![](/.imaging/webp/sanofi-platform/img-w400/dam/myhemophiliatruth-com-hcp/treatment-trade-offs/Kyle_Mobile_2x.png/jcr:content/Kyle_Mobile_2x.png 400w, /.imaging/webp/sanofi-platform/img-w500/dam/myhemophiliatruth-com-hcp/treatment-trade-offs/Kyle_Mobile_2x.png/jcr:content/Kyle_Mobile_2x.png 500w, /.imaging/webp/sanofi-platform/img-w600/dam/myhemophiliatruth-com-hcp/treatment-trade-offs/Kyle_Mobile_2x.png/jcr:content/Kyle_Mobile_2x.png 600w, /.imaging/webp/sanofi-platform/img-w700/dam/myhemophiliatruth-com-hcp/treatment-trade-offs/Kyle_Mobile_2x.png/jcr:content/Kyle_Mobile_2x.png 700w)
What are current and potential approaches to achieving hemostasis in hemophilia?
Each patient story reflects the real-life experiences of individuals diagnosed with hemophilia. Individual experiences may vary. These patients were compensated for their time creating this content.
References: 1. Srivastava A, et al. Haemophilia. 2020;26(suppl 6):1-158. 2. Arya S, et al. J Thromb Haemost. 2022;20(2):296-306. 3. Saxena K. J Blood Med. 2013;4:49-56. 4. Lee Mortensen G, et al. Haemophilia. 2018;24(6):862-872. 5. Skinner MW, et al. Haemophilia. 2020;26(1):17-24. 6. Berntorp E, et al. Blood Rev. 2021;50:100852. 7. Cafuir L, et al. Expert Rev Hematol. 2019;12(7):515-524. 8. Tischer B, et al. Patient Prefer Adherence. 2018;12:431-441. 9. Ljung R, et al. Eur J Haematol. 2019;102(2):111-122. 10. Okaygoun D, et al. J Biomed Sci. 2021;28(1):64. 11. Butterfield JSS, et al. Mol Ther. 2020;28(4):997-1015.
MAT-US-2307282-v1.0-11/2023
Last Updated: November 2023